11
We can use only two famous numbers in mathematics, $\large\pi$ and $\large e$, to produce number $50$.
$$\bbox[8pt,border:3px #FF69B4 solid]{\color{red}{\Large \lfloor e^\pi \rfloor + \lfloor \pi^e \rfloor + \lfloor \pi \rfloor + \lfloor e \rfloor = 50}}
$$
Click the box to see Wolfram Alpha's ...