> I recently ran into a problem where I was was trying to load a 350MB text file into Notepad++, and I got an error saying “File is too big to be opened by Notepad++”. However, another 317.9MB text file opens with no such error.
Actually my file size is 423MB which should not be too big. I closed some programs like MS SQL Server Management Studio and re-open the file with Notepad++ and it worked. Hope closing some programs to free memory is helpful for you too.