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02:01
> Although most Western books were forbidden from 1640, rules were relaxed under shōgun Tokugawa Yoshimune in 1720, which started an influx of Dutch books and their translations into Japanese. One example is the 1787 publication of Morishima Chūryō’s Sayings of the Dutch (紅毛雑話, Kōmō Zatsuwa, lit. "Red Hair Chitchat"), recording much knowledge received from the Dutch.

The book details a vast array of topics: it includes objects such as microscopes and hot air balloons; discusses Western hospitals and the state of knowledge of illness and disease; outlines techniques for painting and printin
@M.A.R. You seem inflamed at the notion
@MetaEd "I don't want to achieve immortality through my work. I want to achieve it through not dying" (Woody Allen)
> Numerous exchanges occurred, leading to a branch of Western learning in Japan known as rangaku (蘭学), or "Dutch learning", where the ran (蘭, "Dutch") in rangaku comes from Oranda, the Japanese word for Holland; gaku (学) is of Sino-Japanese origin and means "learning".[1]
So the ran in Rabgoku is really related to English land.
02:16
My cat is having myoclonic jerks in his front paws when I'm giving him water with a syringe (without the needle of course)
@M.A.R. Why is it that inflammation is a perpetual concern of the "natural" "wellness" types? I'm pretty sure they think absolutely everything is inflammation. Conveniently, every product can somehow be described as plausibly reducing inflammation, so you can sell every "remedy" as a cure for every disease.
No. It's just that inflammation turned out to be involved in a lot of processes.
I'm not criticizing you, just the people in the "everything is inflammation" camp.
Of course, in general inflammation is a good thing, being part of the body's healing process, so it seems odd to claim that it's a dangerous cause of an immense variety of ailments.
02:33
I wonder if humans could be generically modified to have vibrissae
@Cerberus That kanji means Holland and orchid, not land.
@alphabet I see it as one parameter that could be 'tweaked' in some ailments
Orchid is its primary reading outside of jukugo (compounds).
Like, if a person has too much of it in depression, why not dial it down a little
@CowperKettle I really liked those funny musical numbers
02:44
@CowperKettle I like this one better:
Tropic Thunder is a 2008 satirical action comedy film directed by Ben Stiller, who wrote the screenplay with Justin Theroux and Etan Cohen. The film stars Stiller, Jack Black, Robert Downey Jr., Jay Baruchel, and Brandon T. Jackson as a group of prima donna actors making a Vietnam War film. When their frustrated director (Steve Coogan) drops them in the middle of a jungle and dies in an accident, they are forced to rely on their acting skills to survive the real action and danger. Tropic Thunder parodies many prestigious war films (specifically those based on the Vietnam War), the Hollywood studio...
Really more of a satire of movies and Hollywood, though.
The Japanese use many different ordinary objects to combine with other concepts (learning is obviously one, but countries are another). For example, the US is referred to as beikoku (米国) meaning "rice land." It crops up in terms like "Nichi-Bei" (日米), which refers to things pertaining to Japan and the US, like relations.
Japan, of course, is the sun in that relationship.
@Cerberus Also, 国 is the more likely term if you want a word for "land"; it means country, state, region, government, and, of course, land. Its readings are kuni and koku.
Doubtless this is more than you care to know, but it's worthwhile to set the record straight here.
 
1 hour later…
04:07
@Robusto Yeah but Holland is from land. And the Hol- part was apparently dropped.
@alphabet My idea would be as follows. First, inflammation is seen as a potentially bad thing in medical science, by established academics. Secondly, I suspect inflammation is an attack by your immune system upon something it sees as a threat; and we know from many immune reactions that they can often be bad for the body: a necessary evil, damaging the body a bit for the greater good of banishing germs.
04:22
@CowperKettle Much better than being specifically modified :)
I feel better on methylfolate mentally, but still after a run yesterday and after a lot of liquids (tea/coffee) I'm feeling dead tired.
I wish I had a brain sensor for ACTH etc.
Word of the day: mourning wood - having an erection at a funeral
@Cerberus I don't really see your point. My point is that orchid was used to represent your country. That is the first kanji. It has nothing to do with land. The one that does represent land is the second kanji. See above.
@Robusto How is the orchid kanji pronounced, and why was it chosen to represent my country?
@CowperKettle A cross breed between us?
05:39
@Cerberus 蘭 is pronounced somewhat like (r)han (hahn), but it doesn't mean "land", which was your conjecture. It was chosen because of its resemblance to how the Portuguese pronounced the name of your country (“Holanda”). Incidentally, the name "Japan" itself arrived by similar indirect means. It has nothing to do with Nihon, their name for their country.
@Robusto I did not think it meant land, just that it sounded like it.
A translation of a word I wouldn't count as related. I wouldn't say "sea" and "mer" are related, even though they mean the same thing.
 
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13:00
Thus far, with rough and all-unable styles,
Our bending web dev hath pursued the story,
In little RAM confining mighty files,
Mangling by starts the full course of their glory.
Small time, but in that small most greatly lived
This star of England. Fortune made his sword,
By which the world’s best garden he achieved
And of it left his son imperial lord.
Henry the Sixth, in infant bands crowned King
Of France and England, did this king succeed,
Whose state so many had the managing
That they lost France and made his England bleed,
Which oft our stage hath shown. And for their sake,
In your fair minds let this acceptance take.
13:56
The presidential election in Russia will be held on 15–17 March 2024. This will be the eighth presidential election in the country. If no candidate receives more than half the vote, a second round will take place exactly three weeks later, on 7 April 2024. The winner is scheduled to be inaugurated on 7 May 2024. 15 individuals (six self-nominated candidates (independents) and nine party representatives) submitted documents to the Central Election Commission in order to register as candidates.In November 2023, former member of the State Duma Boris Nadezhdin became the first person backed by ...
Nadezhdin was excluded from running today. So all who remain are Putin and candidates who won't make any noise.
Winning over Putin has been out of the question after Feb 2014, but his only issue was with those who could make some noise.
Nadezhdin is an extremely mild candidate who could make the slightest of noises, but he was excluded just to make sure the whole process is airtight.
This is interesting. On the one hand, amazing discoveries in biology and technology. On the other, a slide towards some authoritarian state.
The 3rd updated list of Russian rock bands and other musicians barred from performing in Russia has 50 lines. meduza.io/feature/2024/02/08/…
Not lines. Better to say items, entries, or maybe rows
14:32
The Albert Einstein College of Medicine is a private, nonprofit, research-intensive medical school in the Morris Park neighborhood of the Bronx, New York City, United States. Founded in 1953, Einstein operates as an independent degree-granting institution as part of the integrated healthcare Montefiore Health System (Montefiore Medicine) and also has affiliation with Jacobi Medical Center. Einstein ranks 13th among top U.S. medical schools for graduate success in academic medicine and biomedical research (i.e., awards, publications, grants, and clinical trials), and its NIH funding per investigator...
A magazine published by this research school
14:44
#Worldle #748 1/6 (100%)
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https://worldle.teuteuf.fr
Wordle 964 3/6

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15:13
> My girlfriend's dog died, so to cheer her up, I got her an identical one.
She said "What am I going to do with two dead dogs?"
Daily Octordle #745
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Score: 70
Started out great. Bad finish.
Daily Sequence Octordle #745
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Score: 73
15:29
Word of the day: Panettone - a traditional Italian dessert, a sweet bread made with a rich yeasted dough slowly fermented for even days.
> The word panettone derives from panetto, a small loaf of bread. The augmentative suffix -one changes the meaning to "large bread".
So it's a large small bread
@CowperKettle ... "for even days"?
Oops. For seven days
I figured. Thought you might have time to change it.
> Dutch Letters in Iowa
Much more edible than French letters in the UK
15:44
@CowperKettle At least he's not dead. Yet.
The Russian military has even engaged in anti-raccoon violence
Rootl game #252

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@CowperKettle he was right about that
16:14
@alphabet we're only just discovering how much our immune system affects our body. One important source of damage to any tissue is the immune system doing its job. We only notice it when the balance between regeneration and destruction is disrupted. Everyone has their reasons for claiming inflammation is at the heart of this or that incurable inscrutable disease, and not all of them are out of ignorance or snake oil quackery.
BUT, and this is an important but,
1) "Inflammation" is a very nonspecific term. If any cell anywhere in the body dies unnaturally, it will cause some minor inflammation. You can extract that tissue and say this and this inflammatory marker is increased, but that doesn't prove the underlying cause of whatever you're investigating is immune dysregulation.
2) A lot of useful compounds from plants are antioxidants, meaning, they have lots of -OH groups, so they can scavenge free radicals. Generating radicals is one way immune cells kill bad cells in tissues. It's one way a cell becomes cancerous, or some irreplaceable cell (like a neuron) dies. So people, again not all of them ill-intentioned, like to attribute to these antioxidants the ability to prevent all of that.
UVB causes skin cancer? Try this plant's antioxidants. UVA causes skin hyperpigmentation? Try these antioxidants. Your liver cells are dying? Try these other "hepatoprotective" antioxidants. Your brain cells are dying and you have Alzheimer's? Try these other other antioxidants.
Now, jumping from inflammation being bad for cells to antioxidants being a miracle cure for every untreatable condition is already a bit of a leap, but the main problem here is usually the only evidence we have of these healing properties is some weak irreproducible test where some plant extract neutralized some radical-forming compound like DPPH. The human body is infinitely more complex than the homogenous contents of a test tube.
So big deal that AI is helping people churn out crap papers. We already have our crisis in medicine. People, even those who should know better, worshipping greenery like their god and discarding sound science against it due to basic human irrationality.
So, my point is a lot of bystanders are following the antiinflammatory plant-selling quacks, so of course everyone likes to 'lower inflammation', because the only (weak) evidence out there that their garbage does something is that it can scavenge radicals.
16:40
@M.A.R. There's also this thing where inflammation is a natural response (natural = any one of molecular, intra-cellular, inter-cellular, tissue, systemic (eg the immune system) to many kinds of dysfunction (cell death, trauma, I don't know). That is, there must be some evolutionary reason for it existing (ie it keeps happening so it must not have been selected away, so it must have -some- good effects.
For example, you sprain your ankle and your ankle gets super bruised and swollen (that is both superficial hematoma -and- edema around the joint). And the reasoning is that evolution created those responses as beneficial.
So it can seem counter-intuitive to find that reducing the swelling is -more- beneficial.
@CowperKettle look, saying "Even at low levels, neuroinflammation can have devastating consequences" is akin to saying "Even at low levels, damage to the neurons can have devastating consequences". It's a truism. Unless you have some horrible SCID and don't have neutrophils in your body or whatever, "inflammation" always follows, or is followed by damage to some live tissue. Now, showing which it is is much more difficult and interesting. Showing why neurons are targeted is interesting.
Is there some explanation of why the 'natural' evolutionary creation of inflammation is actually bad, or that it has good and bad features?
Sort of like how fever helps kill off viruses but if it is too bad will kill off the host? or something like that?
Otherwise, drugs that do lower inflammation very effectively, NSAIDs and steroids, they'd have to make me immortal.
@M.A.R. I don't get this.
@Mitch some scientists like calling them "good" and "bad" inflammation. There's no clear line. It's simply a balance. Old buildings have to be demolished for urban renewal. If you're asking why evolution selected for inflammatory processes, you might as well ask why evolution selected for regenerating tissue, as opposed to a static one, like a volvox colony
Now if you nuke the city it allows for a lot of urban renewal, but there's no one left alive to support it, or provide resources for it.
If the inflammation is so strong that it alters how the airways work, it's no longer beneficial, it's harmful to the body, and we call it 'asthma' or a dozen other things, and treat it
@Mitch the scientists in Cowp's link expanded the lifespan of the mice by suppressing an inflammatory cell-signaling pathway.
@Mitch if you reduce the swelling too early, it's not beneficial.
A wound or a lesion leaves the tissues in a state similar to a building half of which is blown up. The immune system has to clean up the debris and blow up the other half so another building can be built in its place.
But let's say the patient is diabetic. That means the blood supply to the tissues is disrupted. It's like saying the streets are always jammed with traffic, so the cement trucks take too long to arrive.
During this time, murderous heroin addict hobos settle in the remains of the flattened building. Bacteria invade the tissues.
The demolition team gets angry and fights off those murderous addict hobos.
Dynamites are being hurled here and there.
The cement trucks still haven't arrived.
Eventually more hobos with different skills and personalities arrive.
The surrounding buildings are damaged due to the hobos breaking and entering, and all the dynamites being flung
Eventually you would have to cut off that block from the rest of the city.
The inflammation people blame the demolition men. They should have known better and not flung dynamites at perfectly good buildings. Maybe they're right. But the real culprit was the traffic jam that didn't allow the cement trucks to arrive on time.
Credits roll. Tom Cruise as Jack, Captain Demolition.
Mads Mikkelsen as Winfrey, the leader of the murderous hobos
Music by Hans Zimmer and Ludwig Göransson
17:05
I saw that last night
Actually I saw Sin City
Vocal theme song by Adele
I don't think Tom Cruise would bother with a movie that was about ineffective traffic patterns for cement construction.
Unless...
Unless Sofia Vergara was his ex-wife and Scarlett Johansson is his current wife.
Or a bunch of Arab terrorists whip the nation into frenzy by trying to undermine American democracy by creating traffic jams
Realizing the true potential in road rages
That's the sequel, BTW. Cement 2: Road Rage
and it turns out that Rosario Dawson, who runs the cement company, is getting paid off by the Union Organizer, played by Frank Whaley.
I think we've moved off of medicine somehow.
Maybe this could be reworked into an animated series based on Fantastic Voyage, but they correct strokes or back pain.
And the drama in the real world parallels the drama inside.
So basically you're saying that inflammation is usually good, but can sometimes overdo it.
Nice. Danny DeVito will be a herb-peddling quack outside and the antioxidant charlatan who convinces the body that it can cure cancer inside, asking for the simple payment of liver.
@Mitch it gets a bad rep because every time there's something bad happening, there's inflammation. For sure, sometimes inflammation itself is the bad thing originally happening, like COPD or autoimmune diseases etc. Sometimes it worsens the underlying problem too.
There's also quite a bit of survivorship bias: Every time the body does manage on its own, when immune cells do contain the damage without invervention, you don't seek medical treatment.
When it can't, the inflammation ends up in a positive loop, manifesting itself as worsening cognition, pain, jaundice etc. depending on where the damage is.
18:02
@M.A.R. I have heard some people say that they now think antioxidants may be a bad thing in some cases, because some level of oxidative stress is required by certain physiological functions, as in articles like this one. But I think that that's currently a somewhat fringe position.
18:37
@alphabet the reason oxidants are bad in the first place is important cellular macromolecules such as DNA and proteins contain aminoacid side chains that can reduce these oxidants, themselves changing shape into something dysfunctional. It's not hard to imagine that, generally speaking, there are also important molecules in the cell that are oxidizing agents themselves, capable of reacting in a chemical environment more conducive to reduction.
Practically though, I'm very skeptical anyone can consume so much antioxidant that this redox balance in the cell shifts so significantly.
The article seems to contain a bit of self-congratulatory "viva la resistance" attitude though I suppose that's more or less in most articles in medicine.
There are unique enzymes naturally in every cell, some specialized cells more than others, whose main reaction byproducts are radicals. That's why cell cytoplasm has so much glutathione: The biggest source of ROS is not UV lights or toxins, it's the cells themselves.
IOW, whenever we've attempted to identify and quantify radicals, we've considered a case of excess radicals due to environmental sources. We've never studied properly the suppression or magnification or natural radical-forming cell processes or enzymes, except in the context of diseases.
So, while my knowledge around these topics is rather superficial, I think that whenever some authors draw a conclusion like "too much antioxidant", they're drawing second-hand unreliable interpretations of data that never aimed to measure natural radical forming processes.
19:27
Wordle 964 4/6

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@Mitch never refer to someone as a current wife
19:51
@MetaEd snort
 
1 hour later…
21:16
@MetaEd ^
See? He used "present" instead of "current" ... makes it OK.
@Robusto credit to Thurber, and of course he's lampooning the practice, not sanctioning it
21:28
@MetaEd Das ist aber selbstverständlich.
This is my favorite Thurber cartoon.
I actually had a chance to act that one once.
Not on stage, but in bed.
@Robusto one of my favorites is the one with the dripping electricity
My then girlfriend lived at Lincoln Park West in Chicago, 23rd floor (IIRC), across the way from Lincoln Park Zoo. We had the balcony doors open off the bedroom, where we were otherwise engaged. So as we were drowsing off to sleep she said, "Listen to all the barking! Isn't it great!" To which I of course replied, "All right, have it your way—you heard a seal bark."
@Robusto nur in unserem Kopf ... weiß nicht, was andere Leute denken würden
@MetaEd Wahrscheinlich kennen sie Thurber gar nicht.
daher könnten sie deinen Witz nicht verstehen
21:40
Das ist nicht mein Witz, aber gehört's Herr Thurber.
"makes it OK" ist dein Witz
Natürlich.
22:37
@M.A.R. What did Herb do that earned him a paddling?
@Mitch Does Frank know who Marsellus Wallace is yet?
22:52
@Robusto Wallace? That jerk? He couldn't find his way out of a doorway.
How did they get access to a documents report that's classified?
> Robert Hur report says he worried jurors wouldn’t believe Biden willfully kept classified materials because they would see ‘a sympathetic, well-meaning, elderly man with a poor memory’.
Ya think?
23:23
@Robusto ok. Try as I might I can't figure it out. Was the guy just asking for her to bark? Like in a sex way?
@Robusto that makes sense if you know that that the wolves in the Lincoln Park Zoo are notorious for howling together at night.
Or were you referring to the seals there? Did they bark loud enough for you to hear them from your (open windowed) apartment?
23:49
For field trips as little kids they would always take us to the somewhat larger Milwaukee Zoo in Washington Park, not the Lincoln Park zoo "in Chicago". It's not it was admission price, either, since the WI one charged a little but the IL one didn't. Mostly because it was easier to get kids to sit still on a bus for 45 miles than for 80, and round trip would have been more than an hour extra in the vehicle. I certainly haven't been since grade school; zoos got me down as I grew older.
This was the 70s, so the giant gorilla was still there.
The Milwaukee County Zoo is a zoo in Milwaukee, Wisconsin, operated by the Milwaukee County Parks Commission and is accredited by the Association of Zoos and Aquariums. The zoo averages about 1.3 million visitors a year. The zoo houses 3,100 animals from 350 species and covers an area of 190 acres (77 ha). The zoo is noted for the second birth of polar bears and siamangs in captivity and for their locally famous gorilla Samson, who lived from 1950 to 1981 and whose bones are now on display at the Milwaukee Public Museum. During World War II, a celebrity animal of the zoo was Gertie the Duck and...
Maybe late 60s. Don't remember what years they took us.
Lincoln Park Zoo, also known as Lincoln Park Zoological Gardens, is a 35-acre (14 ha) zoo in Lincoln Park, Chicago, Illinois. The zoo was founded in 1868, making it the fourth oldest zoo in North America. It is also one of a few free admission zoos in all of North America. The zoo is an accredited member of the Association of Zoos and Aquariums (AZA). The zoo also became an accredited arboretum in 2019.Lincoln Park Zoo is home to a wide variety of animals. The zoo's exhibits include big cats, polar bears, penguins, gorillas, reptiles, monkeys, and other species totaling about 1,100 animals from...
Chicago you went to for the Field Museum. Among other things.

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