Paget's disease of bone (commonly known as Paget's disease or, historically, osteitis deformans) is a condition involving cellular remodeling and deformity of one or more bones. The affected bones show signs of dysregulated bone remodeling at the microscopic level, specifically excessive bone breakdown and subsequent disorganized new bone formation. These structural changes cause the bone to weaken, which may result in deformity, pain, fracture or arthritis of associated joints.The exact cause is unknown, although leading theories indicate both genetic and acquired factors (see Causes). Paget's...

Zoledronic acid, also known as zoledronate and sold under the brand name Zometa by Novartis among others, is a medication used to treat a number of bone diseases. These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone and Duchenne muscular dystrophy (DMD). It is given by injection into a vein.Common side effects include fever, joint pain, high blood pressure, diarrhea, and feeling tired. Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw. Use during pregnancy may result in harm to the baby...

Europe's grey squirrels (Sciurus carolinensis) originated in North America, where they are known as eastern gray squirrels (to differentiate from western gray squirrels). They eat large seeds, flowers, buds, fruits, fungi, some insects and occasionally bird eggs.They were first introduced into England, in a concerted way, in 1876, and through rapidly growing population and further introductions they spread to the rest of Great Britain by the early to mid-20th century. The eastern grey squirrel was introduced to Continental Europe in 1948 and has quickly taken advantage of Europe's food sources...

The red squirrel or Eurasian red squirrel (Sciurus vulgaris) is a species of tree squirrel in the genus Sciurus common throughout Europe and Asia. The red squirrel is an arboreal, primarily herbivorous rodent. In Great Britain, Ireland, and in Italy numbers have decreased drastically in recent years. This decline is associated with the introduction by humans of the eastern grey squirrel (Sciurus carolinensis) from North America. However, the population in Scotland is stabilising due to conservation efforts, awareness and the increasing population of the pine marten, a European predator that...