> Activation of Nrf2 has antidepressant effect, but the specific mechanism remains to be elucidated. This article reviews the key role of Nrf2 in depression, focusing on the possible mechanisms of Nrf2 regulating oxidative stress and related pathological processes in depression treatment.
In stress-resistant mice, the NRF2 signaling is stronger.
Sulforaphane (from broccoli, brussels sprouts, cabbage etc.) activates NRF2, dampens inflammation, and may decrease depression (preliminary studies)
But can also increase cancer cell growth.
So depression might be protective against cancer (?)