hmm. Perhaps it would help to know that $C$ is pointed topological spaces, and that my cospan is simply $* \leftarrow S^1\to *$. And nope, I don't have such a natural transformation... in a sense, it's what I'm trying to build
put differently, I have weak equivalences $F(\ast)\to G(\ast)$ and $F(S^1)\to G(S^1)$ which are compatible with the map $S^1\to *$, and I would like to get a weak equivalence $F(D^2)\to G(D^2)$. oh, and I'd like for it to be compatible with the inclusion $S^1\to D^2$, as well...