@DanielSank from the bible:
But, in principle, one could have also written down the non-relativistic Schrodinger equation for, say, all the electrons and lattice ions in a solid and described the
same physics. This situation is quite different from relativistic quantum
theory, wherein the basic principles demand the existence of antiparticles,
to which there is no simple non-relativistic analogue. Obviously, this has
extra implications that go beyond the fact that we need to deal with sys-
tems having variable number of particles — which, by itself, can be handled comparatively easily.