How some of my conversations with biologists go:
Biologist: "What if you changed the model so that (insert system property here) behaves like this, which is a more accurate description of what is happening in the system."
Me: "I could put that into the model, but I don't see what we would learn from it. I don't think we have enough data to say how the more complicated assumptions would give us a different output than the simpler assumptions."