https://www.explainxkcd.com/wiki/index.php/1520:_Degree-Off
> Science Girl then goes on to directly accuse Cueball (i.e. physicists) of creating a new Horseman to replace the one slain by the biologists. She claims that they gathered in the desert to do so. Given Cueball's opening remark, she must be referring to the development of the atomic bomb, which was built and tested in the New Mexico desert. The new horseman is therefore the atomic bomb, or the various perils associated with it.