There's the original statement, and then there are many generalised statements, and slight analogous statements, so in some sense there are many 'period-index' problems. The classical problem is to answer the question:
What is the minimal $l\in\Bbb N$, dependent only on the underlying field $k$, such that $ind(A)|per(A)^{l}$ for all central simple $k$-algebras $A$?