Reactions that form 6 membered rings most commonly go via either boat or chair transition states but the products themselves do not necessarily adopt the same conformation as the TS. I'm attempting to model a cyclisation in which an amine attacks a pi system to form a new ring, giving rise to t...

I didn't have much time to participate this fall, and I'm excited to see the synthesis golf questions. Idea: I'd like to suggest possibilities for “molecular design golf” (name TBD). These are questions that point to the diversity and design aspects of chemistry. Some might include or require c...