Molecular level interlocking--do you mean like intermolecular bonding between the tire and road? If we are talking about mechanical effects still, I'd imagine a tire with a textured surface inherently has more "domains" to interlock with the road. I do agree the tread isn't too important, if only because it wears off after <500km.
As supple as modern road tires are, I'm not convinced they are able to effectively conform to the <1mm bumpiness on a road surface purely by pneumatic means.