English Language & Usage: Multi-Layered Discourse Room

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12:54 AM

“diazepam normalizes hippocampal perfusion in individuals at clinical high risk for psychosis” - by normalizes they mean 'diminishes'

alphabet

1:21 AM

Word of the day: snail trail. I had the misfortune of encountering this slang term for the first time today and had to look it up. Fair warning, the definition is...yuck.

(At least I think so. If straight guys find definition (1) appealing, Imma go throw up in my mouth a bit.)

Xander Henderson

2:15 AM

@alphabet Just about everything related to sex is rather gross. All those fluids and whatnot. Yech.

CowperKettle

Word of the day: Turing–Chomsky Compression

> We integrate two traditionally separate fields of study (generative grammar and active inference) to propose a new design principle for human language: Turing–Chomsky Compression. link.springer.com/article/10.1007/s11229-024-04566-3

CowperKettle

2:42 AM

Hm. Looks like carbamazepine increases one's cholesterol: The proportion of patients with elevated total cholesterol levels (above the upper limit of the reference range) did not change in the LCM treatment group (37.0% at Baseline; 34.8% at 12 months), but increased from 30.8% (at Baseline) to 49.6% (at 12 months) in the CBZ treatment group.

ncbi.nlm.nih.gov/pmc/articles/PMC7756649

My brother's cholesterol levels were found to be elevated. He should probably start on statins.

Or switch to an antiepileptic drug w/o this side effect.

CowperKettle

2:57 AM

> " diazepam normalized hippocampal hyperperfusion in Critical High Risk of Psychosis individuals, consistent with evidence implicating medial temporal GABAergic dysfunction in increased vulnerability for psychosis" nature.com/articles/s41386-024-01864-9

CowperKettle

3:14 AM

Current weather e1.ru/text/spring/2024/05/04/73539662

2 hours later…

CowperKettle

5:14 AM

Cholesterol Denialism is Pseudoscience - it's hard to understand for me why there is so much fuss about this. Maybe statins really don't decrease mortality much in absolute terms? Too complicated.

> In 2023, the World Heart Federation published a report which stated that high levels of low-density lipoprotein (LDL) cholesterol are a major risk factor for cardiovascular diseases and that elevated LDL cholesterol contributed to 3.8 million deaths in 2021.

Lipid hypothesis

The lipid hypothesis (also known as the cholesterol hypothesis) is a medical theory postulating a link between blood cholesterol levels and the occurrence of cardiovascular disease. A summary from 1976 described it as: "measures used to lower the plasma lipids in patients with hyperlipidemia will lead to reductions in new events of coronary heart disease". It states, more concisely, that "decreasing blood cholesterol [...] significantly reduces coronary heart disease". As of 2023, there is international clinical acceptance of the lipid hypothesis. == History == In 1856, the German patholo...

1 hour later…

M.A.R.

6:38 AM

@CowperKettle because these people prattle "correlation doesn't imply causation" like a religious hymn. I have the rare experience of both studying drugs and being a long-time consumer. Sometimes one develops this irrational dislike of having to take drugs that manifests itself in a variety of ways, including skepticism.

I mean, having to take pills outright depresses some people.

1 hour later…

CowperKettle

7:42 AM

> A study by Jeukendrup et al. found that exogenous carbohydrates could only provide 5–15 g as an energy source during the first hour of exercise. Such amounts have a very weak effect on delaying muscle glycogen depletion [4]. mdpi.com/2072-6643/16/8/1248

So... eating carbs during a bicycle ride could be a dumb idea if the ride is less than 1 hr?

Studies in sports medicine just reek of shoddiness.

Everything is done on a sample of "me, my friend Bob and my dog"

6 hours later…

alphabet

1:42 PM

@CowperKettle In this case, I think it's because advocates of ultra-low-carb diets, particularly ones that include a lot of meat, want to prove that diets with high levels saturated fat aren't dangerous. That's the context I've heard this in.

@CowperKettle If you get hungry during your bike rides, presumably you should eat something. But I doubt there's any reason to deliberately ingest extra calories in an attempt to improve performance.

alphabet

2:16 PM

Word of the day: shut-up ring. A perfunctory engagement proposed by someone who doesn't actually want marriage.

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