@Takkat - I know you're big on the audio troubleshooting. I recently had a weird one where audio was glitched to muted and normal service restarts weren't working. I had to edit /etc/pulse/default.pa and turn off the three modules that deal with restoring device state, reboot, mute and unmute in both alsamixer and the sound control panel, uncomment the restore state lines, and reboot again.
I think it was related to a client.conf to make pulse not automatically restart when killed, but I can't replicate the problem now.