Elisabeth Binder is a medical doctor and neuroscientist specializing in the study of mood and anxiety disorders. She is the director of the Department of Translational Research of the Max Planck Institute of Psychiatry in Munich, Germany. In addition to research, she is a member of the executive committee of the European College of Neuropsychopharmacology (ECNP). == Career == === Education === Binder received her MD from the University of Vienna (1995) and completed her PhD in Neuroscience at Emory University in Atlanta, Georgia (2000). Since 2004, she has been an associate professor in...

SAFit2 is a drug which acts as a potent and selective inhibitor of the signalling factor FK506 binding protein 51 (FKBP51), which is involved in the downstream response to glucocorticoid release in the body. Since elevated glucocorticoid levels are a characteristic marker of chronic stress, blocking glucocorticoid signalling pathways using SAFit2 has been shown to counteract many of the associated symptoms such as obesity, chronic pain, depression and anxiety, and addiction. While SAFit2 itself is a relatively large molecule and is unlikely to have suitable properties to be developed for medical...

Seasonal affective disorder (SAD) is a mood disorder subset in which people who typically have normal mental health throughout most of the year exhibit depressive symptoms at the same time each year. It is commonly, but not always, associated with the reductions or increases in total daily sunlight hours that occur during the summer or winter. Common symptoms include sleeping too much, having little to no energy, and overeating. The condition in the summer can include heightened anxiety.In the DSM-IV and DSM-5, its status as a standalone condition was changed: It is no longer classified as a unique...

Le funiculaire de Montjuïc est un moyen de transport de la ville de Barcelone en Catalogne en Espagne qui facilite l'accès à la colline de Montjuïc. La ligne est principalement en tunnel et est connectée au métro de Barcelone par la station Paral·lel (Ligne 2 et 3). La station supérieure du funiculaire (Parc de Montjuïc) est située à côté de la station inférieure du téléphérique de Montjuïc donnant accès au château de Montjuïc. Le funiculaire est l'un des trois en service à Barcelone avec le funiculaire du Tibidabo et le funiculaire de Vallvidrera, tous trois exploités par TMB. == Histoire... ==

El Teleférico de Madrid comienza en el paseo del Pintor Rosales y termina en la Casa de Campo. En su trayecto sobrevuela la rosaleda del Parque del Oeste, la estación de cercanías de Príncipe Pío, la ermita de San Antonio de la Florida y el río Manzanares y termina junto a la plaza de los Pasos Perdidos de la Casa de Campo (cerro Garabitas). En esta terminal hay un restaurante-cafetería y un aparcamiento para automóviles y en la del paseo de Rosales otro aparcamiento, con 350 plazas, y un restaurante, El Balcón de Rosales, explotado por la misma empresa propietaria del teleférico. == Historia… ==

The Duquesne Incline ( dew-KAYN) is a funicular located near Pittsburgh's South Side neighborhood, scaling Mt. Washington in the United States. Designed by Hungarian-American engineer Samuel Diescher, the incline was completed in 1877. The lower station is in the Second Empire style. Together with the incline, which rises 400 feet (122 m) in height, at a 30-degree angle, it was listed on the National Register of Historic Places in 1975. The incline is unusual for having a track gauge standard used only in Finland, Russia, and Mongolia. Together with the Monongahela Incline, it is one of two passenger...

The Broadmoor Manitou and Pikes Peak Cog Railway (also known as the Pikes Peak Cog Railway) is a cog railway that climbs one of the most iconic mountains in the United States, Pikes Peak in Colorado. The base station is in Manitou Springs, near Colorado Springs. Construction on the line was started in 1889 and the first train reached the summit on June 30, 1891. Cog railways are common in Switzerland and found in other parts of the world (totaling about 50 lines), but this is one of only three such lines remaining in the United States, the others being the older Mount Washington Cog Railway in...

Le funiculaire de Montmartre, situé dans le 18e arrondissement de Paris (France), est depuis 1991 un ascenseur incliné automatique comprenant deux cabines permettant de monter au sommet de la butte Montmartre et d'accéder ainsi à la basilique du Sacré-Cœur sans devoir emprunter l'escalier de 222 marches. Ouvert en juillet 1900, il a été entièrement rénové en 1935 puis transformé en 1991. Long de cent-huit mètres, il gravit les trente-six mètres de dénivelée en moins d'une minute trente. Géré par la RATP, l'opérateur des transports en commun parisiens, il a transporté un peu plus de 3 400 00...

The Monongahela Incline is a funicular located near the Smithfield Street Bridge in Pittsburgh, Pennsylvania. Designed and built by Prussian-born engineer John Endres in 1870, it is the oldest continuously operating funicular in the United States. It is one of two surviving inclines in Pittsburgh (the other is the nearby Duquesne Incline) from the original 17 passenger-carrying inclines built there starting in the late 19th century. Its lower station is across the street from what is now the Station Square shopping complex. It is easily accessible from the light rail system at the Station Square...