In particular, there should be a natural map from homology of X to homology of π₁(X), and I want to know what the fundamental class of X is being sent to
What [X] is sent to can encode a lot of information, it seems! E.g. if X_2 is K(π₁(X),1), it must be sent to 0. And there is a result in 4-manifolds that says that a smooth 4-manifold up to ℂP² is given Euler characteristic, signature, π₁ and the image of [X].