And now I have an idea for a crazy design: one looped rectangular belt, and everything else inside of that belt. Inserters can only be used to move stuff to and from the belt - no passing between machines. Fluids must be barreled, placed on the belt, and unbarraled in place. Design must be capable of repeatedly launching rockets (so the belt can't become saturated to the point that rocket production is no longer possible due to some machine not being able to put its output on the belt).