\documentclass{standalone}
\usepackage{tikz-cd}
\begin{document}
$$
\begin{tikzcd}[column sep=-1cm]
& A
\ar[ddd, controls={+(-5,0) and +(-5,0)},
start anchor=west,end anchor=west]
& B \\
& C
& D\\
E(BIG THING) & & \\
& F(BIG THING HERE, TOO)
&
\end{tikzcd}
$$
\end{document}