Example vehicle, just to get the feel about it:
If we use a RD-0410 nuclear engine, (perhaps a bit unfair, as it was just a prototype, but its parameters can be used as a lower bond). To have a thrust to weight ratio larger than 1.5, the shuttle can be approximately 25000 kg fully loaded. From the loooooong list of upper stages listed at encyclopedia, it seems that the totall mass to dry mass ratio is approximately 12. If we assume a ratio of perhaps 10 for the mass not including the engine, we can have 20700 kg of water. I chose to round that down to 20000 kg to have some margins. After a …