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
I'll add two more examples to the mix: Let $K \subset S^3$ be a knot, then $M = S^3 \setminus K$ is a $K(G, 1)$ space. This following from Papakyriakopoulos's sphere theorem: if $\pi_2M \neq 0$ then there's an embedded PL sphere $S^2 \to M \subset S^3$ which is not nullhomotopic. By Alexander's t...