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
To be concrete, here's my answer: If $X$ and $Y$ are second-countable and if $X$ is locally compact Hausdorff, $C(X,Y)$ is second-countable. Proof:
Being second-countable locally compact Hausdorff, $X$ admits a countable basis whose every basic open set has compact closure; let $\mathcal{U}$ be o...