"Mayer Vietoris says that to work out the obstructions in AuB, that's like taking disjoint copies of A and B and looking at their defects, and then counting the ones you counted twice from their intersection that you ignored: it is the inclusion exclusion principle. The snake lemma tells you that if you were looking at n-dim holes, then you next need to take into account the n-1 dim holes - or the boundaries of the n-dim holes."
https://www.physicsforums.com/threads/exact-sequences.164213/