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Can every function $f : \{0,1\}^* \to \{0,1\}$ that is computable in time $t$ on a single-tape Turing machine using an alphabet of size $k = O(1)$ be computed in time $O(t)$ on a single-tape Turing machine using an alphabet of size $3$ (say, $0,1,$ and blank)?
(From comments below by the OP)
Not...