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02:20
Hi, anyone here?
 
4 hours later…
06:03
Morning. How might taxation organization be called?
Tax office?
Tax inspectorate?
Revenue Service (in the US)?
A revenue service, revenue agency or taxation authority is a government agency responsible for the intake of government revenue, including taxes and sometimes non-tax revenue. Depending on the jurisdiction, revenue services may be charged with tax collection, investigation of tax evasion, or carrying out audits. The chief executive of the revenue agency is usually styled as Commissioner, Minister, Secretary or Director. == Revenue services by territory == Albania - Drejtoria e Përgjithshme e Tatimeve / Γενική Διεύθυνση Φορολογίας / Albanian Taxation Office and Inland Revenue Argentina -...
The Federal Tax Service (In Russian: Федеральная налоговая служба, ФНС России) is a federal body of executive authority responsible for carrying out state registration of legal entities and natural persons as individual entrepreneurs and farmsteads. Formed in March 19, 2004, after the dissolution of the Federal Tax Police Service of the Russian Federation, whose functions were split between the new Federal Tax Service and the Taxes Crimes Department of MVD (Управление по налоговым преступлениям МВД). It is also a federal body of executive authority responsible for ensuring the presentation of claims...
0
Q: "is just a recommended minimum" vs. "is just the recommended minimum"

CowperKettle At least two orthogonal studies should be performed to establish comparability. However, this number is just the recommended minimum, and is not optimal. Since the first sentence makes the recommendation, I think that it is okay to use the. At least two orthogonal studies should be per...

Thanks.
You're welcome!
06:49
Hello everyone :-)
"Would you care to reply my email" is this sentence grammatical ?
07:03
> If the comparability exercise in the in vitro studies in step 1 is considered satisfactory and no factors of concern are identified in step 2, or these factors of concern do not block direct entrance into humans, an in vivo animal study may not be considered necessary.
What is the meaning of this "may not", @M.A.R.?
Is it prohibitory?
Or is it "optional"?
@EngFan "to my email"
@CowperKettle : hello
"Would you care to reply to my email" is this sentence grammatical ?
@CowperKettle It means that if those conditions are met, we should ideally not need an animal study. However, there might be other causes that necessitate animal study and if so, whether or not these conditions are met, it will be conducted
@EngFan Yes, it's grammatical
Anonymous
@EngFan You should add a question mark.
@M.A.R. Thank you! So it's optional
Good noon, Snails
@snailplane \o
07:12
@snailplane: hello !! , sure
07:24
I wonder if test panel is a term only relevant to diagnostics
Could it be used to describe a series of tests performed to assess the toxicity of a biosimilar drug?
Can we "perform a test panel"?
''perform a panel''? O.o
No?
How then to use it?
"Perform a panel of tests"?
What's the whole sentence?
0
Q: Usage of the term "test panel"

CowperKettleIs the term "test panel" only applicable to the diagnostic process? Could it be used to describe a series of tests not intended to diagnose a disorder? Perform a panel of tests in a relevant animal model in order to determine the toxicity of the biosimilar drug product. Would this look oka...

Namaste, @SreeCharan
@CowperKettle Namaste.. Are you an Indian?
07:32
@SreeCharan Nope, he just likes helloing in thirty different languages
@SreeCharan I'm Russian
@M.A.R. OK. I just checked his profile.
@snailplane : does that sentence sound rude?
@CowperKettle : do u speak Hindi too???
@CowperKettle are you a multi linguist?
07:35
@SreeCharan No... no
@SreeCharan multilingual
Haha, that'll teach you to ''Namaste'' people next time @Cowp
I just spend too much time in chats, and my time zone is the same as the time zone in New Delhi so..
I picked up several words
@CowperKettle OK, pop quiz
@CowperKettle What's ''entrepreneurship'' in Hindi?
@M.A.R. OK. I thought of multilingual. But when I googled the word multi linguist, a dictionary showed this collinsdictionary.com/dictionary/english/multilinguist
@Hi @M.A.R. Could you help me please?
@DamkerngT. @snailplane Please help with this question
He was conferred (a)/ to his bed (b)/ by illness.(c)/ No error(d)
07:44
@M.A.R. I think is dhamdha or vyavasaay.
@SreeCharan Fair enough, but then you shouldn't put a space between ''multi'' and ''linguist''. It's one word
@M.A.R. When I typed, multilinguist, it showed a red line. So gave a space. Does SE follow American english?
@SreeCharan Forget the spell-checker.
That's the spell-checker in your browser that highlights spelling errors.
@SreeCharan dhamdha sound nice
@CowperKettle dhamdha is used more by natives in India.
@M.A.R. Disabled it.
07:50
@SreeCharan I don't disable it, because I find it useful for avoiding typos.
But when you're sure a word exists, it's usually the spell-checker that is at fault
Anonymous
@SreeCharan Spell checkers just match things against word lists. Multilinguist isn't a common enough word to be in the lists used by most spell checkers.
Anonymous
But it should not be written with a space, because multi- is a prefix, not an independent word.
Anonymous
This is unrelated to the question of American versus British English.
@snailplane. Hello. OK.
Anonymous
07:52
@user62015 Confer seems like a strange choice of verb.
Anonymous
Perhaps they're testing you to see if you can tell the difference between confer and confine.
yes
confer is odd
> to compare views or take counsel
I never knew of this sense
Time for an avatar change!
> During the clinical development programme, patients are normally enrolled commensurate with the level of evidence obtained from preceding steps which support comparability.
I don't understand this sentence at all
who is commensurate?
what is commensurate?
enrollment is commensurate?
or patients are commensurate?
if the level of evidence is high enough for step 1, then patients are enrolled for step 2?
0
Q: Meaning of "patients are normally enrolled commensurate with the level of evidence obtained from preceding steps which support comparability"

CowperKettleFrom this Guideline: Comparative clinical studies between the biosimilar and reference medicinal product should always be conducted. The number and type of studies might vary according to the reference product and should be justified based on a sound scientific rationale. A stepwise approach ...

08:10
@CowperKettle Patients are normally enrolled, commensurate with the level of evidence obtained from preceding steps, which support comparability
@CowperKettle Yes
@M.A.R. ah, then the official Russian guideline, which really a mish mash of translations (including from this document) has it wrong.
They should have hired me to translate that into Russian.
@CowperKettle Enroll E. Commensurate was a scientist.
@CowperKettle CURSE THEM!
Bless them, for I'm now proofreading a back-translation to English
Some money for me
this backtranslation goes like this
> During the clinical development programme, enrolled subjects should correspond to the level of evidence obtained from preceding steps.
which stumped me
Heh
I remember the Bad translator site
08:33
2
Q: "being there such differences" - is this an acceptable turn of phrase?

CowperKettle All studies should be directed at identification of potential differences between a biosimilar drug and a reference drug, and on assessment of their significance (being there such differences). Is this an acceptable phrase? I would have written "when such differences are detected" or "should...

08:51
Hi! Is it illegal to share an e book to someone after buying?
Not illegal, but perhaps unethical
Nods...
Why some good books are available free and some has to be bought ? I was searching for a book by Dominic o Brian.
I don't even have credit card. Next, The book is very expensive to buy.
09:24
0
Q: can we omit "the" in "The primary objective of (the) pharmacokinetic studies performed to support a MAA .."

CowperKettleFrom an EMA guideline: The primary objective of the pharmacokinetic studies performed to support a MAA for a biosimilar is to show comparability in pharmacokinetics of the biosimilar with the reference medicinal product in a sufficiently sensitive and homogeneous population. This is expected ...

Anonymous
09:50
I'm voting to close this question as off-topic because it's about programming culture, not English in general, and we can't guarantee good voting on answers. — Nathan Tuggy 14 mins ago
Anonymous
But then wouldn't we have to close lots of questions? For example, everything on grammar . . .
Anonymous
We can't guarantee good voting on answers on lots of topics on ELL.
@snailplane I think what he meant is that it's gonna derail into opinionated answers and passionate programmers fighting?
-15
Q: Why is there only one vote button?

ZirWhy doesn't an answer have two vote buttons, one for the effort and one for the accuracy? You know some people spend some time to answer questions and probably they answer the wrong way. So, why give them only down votes?

You are my hero. — Teacher KSHuang 28 mins ago
Heh, this guy is sooo dramatic
Can anyone recommend a good movie?
10:18
Sure
Which director?
Which genre?
@SreeCharan Do you like dark and grim movies, psychological movies, action movies, scientific movies, drama, or what?
@M.A.R. Not specific about director(I barely know the names of them). comedy, drama, socio-fantasy.
Interstellar is a nice sci-fi and scientific movie.
Hmm, comedy you say? Unfortunately, IMO the worst movies are comedy.
But hmm, what about ''Why Him?''
That's an OK comedy
''The Other Guys'' is an action-packed film with a lot of funny scenes
''Anchorman'' and ''Anchorman 2'' are supposed to be among the best comedy movies @Sree, but I didn't find them worth watching.
I grew tired almost in the middle.
''Megamind'' is fun. @Sree do you watch animated movies?
@M.A.R. Yes i do. I have watched it.
Oh, good.
Have you watched ''Inside Out''?
I find Disney Pixar's animated movies more watchable than most movies.
''Toy Story 3'' is just fantastic.
@M.A.R. No. I watched toy story series. I like them.
10:34
@SreeCharan You should definitely watch all of Pixar's animations except Cars.
And Cars 2
WALL-E is magnificent
@M.A.R. Unfortunately, I have watched both.
@SreeCharan Depending on whether or not you also like to watch movies that make you think hard, I can recommend some movies. Do you like such dark movies?
Well, not dark per se.
I'm not talking about horror.
Dark means? example?
Like ''The Dark Knight''
Gawd, the best movie in all the worlds
@M.A.R. Keep them coming. I'll note down.
10:37
OK.
Basically, everything that Studio Ghibli of Japan and director Christopher Nolan have made are amazing and awesome to watch.
Insomnia
Memento
Batman Begins, The Dark Knight, The Dark Knight Rises
Inception
The Prestige
Interstellar
Those were Nolan's movies.
There's also one coming to cinemas in July.
It's called ''Dunkirk''
Spirited Away
Princess Mononoke
Ponyo
Those are the best Studio Ghibli movies.
There are also movies from other awesome directors like Scorcese, Kubrik and Spielberg that I like.
Munich from Spielberg
Shutter Island from Scorcese
The Revenant from Gonzalez
Pulp Fiction from Tarantino
The Hateful Eight from Tarantino
A beautiful Mind by Howard
Dawn of the planet of the apes by Reeves
Also Rise of the planet of the apes

Movie Recommendations

14 mins ago, 7 minutes total – 23 messages, 1 user, 0 stars

Bookmarked just now by M.A.R.

@Sree I made a bookmark, so you can access the list whenever you want.
10:54
Thanks a lot @M.A.R.
11:32
0
A: "Whether he met them (IT) is not clear." Do I have to insert an 'it'?

AraucariaWe can use clauses as Subjects in English: [That she refused your offer] is not surprising. [Whether you like it] is not important. In the sentences above we see a declarative clause and an interrogative clause functioning as Subjects. However, sentences like these are not very common in E...

Ha ha. I'm back on chat again ... :-)
12:20
@Araucaria welcome back :-)
12:32
What kind of books we are supposed to request for ? Is this sentence correct grammatically?
Good Evening All!
I think this comma is in the wrong place
after 'justified'
> The following factors impact on the strategy of designing PK evaluations.
Is it okay to use the word "following" and not end the sentence in a colon?
Good evening, @yubraj
"for" is out of place there, @yubraj
@Man_From_India Hi!
@yubraj You don't need for. "We are supposed to request [what kinds of books]?" --> "[What kind of books] are we supposed to request?"
evening, @Araucaria
@CowperKettle Evening KC!
A man from Yekaterunburg pictured today. Drinks coffee, reads Shopenhauer
A lot of my friends went ice bathing but I have no time
12:49
@CowperKettle I love this guy!
He must really love reading!
Good evening, everyone!
@M.A.R. Why so old bean? It doesn't seem to be any different from sharing a physical book ... (and often the e-books are more expensive than the physical ones!)
@CowperKettle oops, CK, sorry!
13:18
Hi
What's the difference between (The next is only a descrption of something) "Opens home menu" and "Open home menu"
Who is the person of "Opens", It?
I'm not english
@CowperKettle Nods..
@Araucaria Thanks
@yubraj Can you help me?
:(
I will kill myself
13:43
Oh!
Why?
He, she, it=opens
I, we, they=open @SinNombreSinApellido
@SinNombreSinApellido Can I help?
@SinNombreSinApellido Di me
I readed a description like that:
Red button - Opens something
But is that correct?
Yes
13:49
@SinNombreSinApellido Looks good to me!
@SinNombreSinApellido i think not. Red button - Closes something.
xD
Thank you all
@SinNombreSinApellido De nada!
+Araucaria - Muchas gracias jaja! :P (Thank you so much)
Wellcome
13:51
Thanks again :P
I will back when I have another question
Baaaay guyyssss
Can I say 'Hi guys' in formal context? @dem @snail
@yubrajWhat Not in any very formal context, no ...
13:56
@yubraj this may help you
in JavaScript on Stack Overflow Chat, 35 secs ago, by Oliver Salzburg
@LearnHowToBeTransparent In a formal context, it is preferred to say "Whaddup"
As we are chatting here in this chat box, isn't a formal context ? I think It's. In my opinion, "guys" refers to both man and woman.
@DamkerngT. @snailplane @Man_From_India @mike @M.A.R. Any chance of helping to reopen this question:
0
Q: This question needs reopening, please

AraucariaThis question here: 'She was shot by police yesterday' or 'She was shot yesterday by police' was closed as a duplicate of this question here: Where is the correct place to place adverbs in sentences? The first one is about Adjuncts/Adverbials and the second is about adverbs. However, Adju...

@yubraj this is not a formal context.
@yubraj Yes, what Learn just said ... It's not formal.
Oh!
I'm not sure yet @Araucaria @LearnHowToBeTransparent
14:00
@yubraj disclaimer: i am not a native english speaker
@LearnHowToBeTransparent I am, you're right ... :)
@yubraj Anywhere where people regularly use abbreviations like "btw" or "thanx" isn't formal :) Also anything that is considered chat is definitely not formal. Chat specifically means informal, relaxed and casual speaking :-)
Nods...
Why I said 'chat' is formal here is because this chat box is for all the ELL users. We all are being polite here. It's something like formal.
IMO
0
Q: This question needs reopening, please

AraucariaThis question here: 'She was shot by police yesterday' or 'She was shot yesterday by police' was closed as a duplicate of this question here: Where is the correct place to place adverbs in sentences? The first one is about Adjuncts/Adverbials and the second is about adverbs. However, Adju...

14:18
@yubraj Formal, polite and friendly aren't the same things. They're very, very different ...
14:30
> It should be taken into account that the pharmacokinetic profile of the product may not correspond to the changes in the profiles of PD markers produced in response to the drug product administration.
I wonder if this is natural.
Thoughts about the (a)/ slaughtered children (b)/ is uppermost on my mind.(c)/ No error(d)
Section A shows an error but I am not sure what is the error?
are
Thoughts are
Thought is
Thanks.
but do you think thoughts about is fine?
or we must omit about here?
you cannot omit 'about' here
14:45
Thanks.
Maybe "The thought about the slaughtered children is uppermost on(in???) my mind"
I'm not sure about in/on
Yes. I agree.
15:07
@yubraj So we can be formal but be rude and we can be formal and be unfriendly. We can also be very informal but polite and friendly! :-) [For example think about smileys/emoticans. They're very, very informal. But we use them to be friendly and polite!]
15:43
> In particular, the invention concerns the use of such antagonists to treat autoimmune disease in a mammal who experiences an inadequate response to a TNFα-inhibitor.
is this a generic noun phrase?
16:18
> Percentage of patients achieving clinical response based on the American College of Rheumatology's 20% improvement criteria.
Do I need the possessive 's here?
16:52
What does "true to it's reputation" mean?
its
It means the person (or thing) is exactly as people believe it to be
@CowperKettle :oh !
Yup "its".
And "true to my senses"?
Haven't heard it before.
17:26
Well, I will die ignorant. Nobody answers my question. Lol.
@V.V. : We are in the same boat .😆 LOL
 
1 hour later…
18:35
@Araucaria Eh, dunno
19:00
Do we have a tag for preposition stranding?
Ah, you're serotonin now
19:22
For the umpteenth time...what a nice phrase!
2
19:34
> For example, those in the north-eastern states (such as Connecticut, Delaware, New Jersey and New York) were more likely to swear whereas people were less likely to in the southern states (South Carolina, Arkansas, Tennessee and Mississippi).
Hah!
And I thought people from the south swear more often!
(Like, they're tough men. :)
no, southerners in the US are considered more "gentlemanly"
I read about it some time ago
19:55
Word of the day: Ostinato
3
I had no idea what that means!
BTW, you've got a new avatar!
yep
@DamkerngT. I was reading what Zimmer said about how he composed ''Interstellar'''s soundtrack.
A-ha!
Makes sense. It sounds like something he would say. :D
Italian is the language of music.
 
1 hour later…
21:07
> A Northwestern University team developed a new computational model that performs at human levels on a standard intelligence test. This work is an important step toward making artificial intelligence systems that see and understand the world as humans do.
> While Forbus and Lovett's system can be used to model general visual problem-solving phenomena, they specifically tested it on Raven's Progressive Matrices, a nonverbal standardized test that measures abstract reasoning. All of the test's problems consist of a matrix with one image missing. The test taker is given six to eight choices with which to best complete the matrix. Forbus and Lovett's computational model performed better than the average American.
 
3 hours later…
23:51
@CowperKettle It would be very odd in an academic register to use who for mammals there (although it shouldn't be, imo). You probably want to use which ..
@CowperKettle No, but it does no harm ...

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