MatrixPlot[RandomInteger[{0, 1}, {10, 10}],
FrameTicks -> {
{{1, "my house"}},
{{1, "yo house"}, {8, Framed@Column[{
"ergo, you too far to do anything.\n now look at this plot:",
Plot[x^2, {x, 0, 1}]}]}},
{{1, "yo mamma house"}, {2, "B"}},
{{1, "yo sista house"}}}]