There are plenty of threats out there that could terminate all life on our little planet in varying amounts of time. (Solar flares, meteors and supernovas to name a few).
Are there any disasters that could kill all (intelligent) life on Earth but leave astronauts in low orbit alive for long enou...
My initial impression is that it's too opinion-based, because the kind of computer which could actually simulate our reality is so far beyond our current understanding that we'd have to speculate about its nature.