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Some comments says that the oldest manuscripts do not contain "in Ephesus" e.g. Jamieson-Fausset-Brown Bible Commentary, Scofield Reference Notes, Clarke's Commentary on the Bible...
What can we conclude from the text in Greek?
Ephesians 1:1 (NA28)
Παῦλος ἀπόστολος Χριστοῦ Ἰησοῦ διὰ θελήμα...