There are many, many airplanes these days with GPS. (or tablet with mapping software) Whether or not the screen displays wind doesn't really matter, it's easy enough to follow the magenta line and in doing so, correct for the effects with no math or E6B tomfoolery. But I've never seen any plane with a sideslip vane. (unless that's yarn on a glider?) Taking out sideslip is what the balance ball is for.
What is a "meaningful" estimate of sideslip angle? Generally the goal should be zero, right?
@quietflyer, again I will quote from your answer: "Since we usually fly with zero sideslip as best we can, and experience no more particular tendency to slip when flying crosswise to the wind than any other time, your questions are pretty much moot as far as all practical flying and navigation is concerned."
So why then do we need/want to know the actual angle?