One thing to look at is whom they benefit/harm. Bards, Sorcerers, and Warlocks are hit pretty hard: the only positive they can really look to is the CON-bumping things, but those cost them CHA-effects.
Rogues are pretty well screwed, with DEX, INT, and CHA being the three negatively-hit.
Monks, Paladins, Fighters are pushed toward WIS (monk) or STR (fighter, paladin) and away from DEX (monk, fighter) or CHA (paladin).
Wizards are alright--I suppose the +CON/-CHA thing is a mild benefit at likely no cost.