Discussion on answer by SeriousBri: What is the appropriate spell level for this homebrew spell (Devolve Person), intended as a mental counterpart to Hold Person?

@Andrendire: As has already been discussed, failing dex saves is usually just about damage, not further / longer-term status effects. Banishment is only permanent on creatures not native to this plane. (Unless the party is off the prime material, that's rare for humanoids). Plane Shift isn't lethal for creatures that can plane shift themselves out again. Symbol can impose "hopelessness" (no attacks or harmful abilities for 1min). Forcecage + AoE effect is one of very few killer effects that depends on Cha saves (or not being able to teleport, e.g. by blocking spellcasting.)

@Andrendire: And note that Hold Person / Monster itself is a Wis save to resist, not Cha. So you get a "major" save to resist paralysis.