I don't know if there's a clean way to do that without removing the node (meaning fail all active instances on that machine to other nodes). It is just temporary, you can add the node back once you've removed the instance you don't want.
Cluster or not, doesn't matter, there may be some really hacky ways to get away with it, but they'll leave you unsupported and probably broken in not-immediately-obvious ways'
@CraigEfrein Why? You can have a single-node cluster (again, temporarily)