Probably something trivial that I'm not seeing right now. Is it true that [C^T, D] \cong [C, D]^{[T, 1_D]} for a comonad T? In the nlab page
ncatlab.org/nlab/show/Eilenberg-Moore+category#Street72 , it says that this is true. On the other side, not every functor C^T --> D lifts to a functor C --> D since some morphisms in C are not algebra morphisms.