\documentclass{beamer}
\beamertemplatenavigationsymbolsempty
\setbeamersize{text margin left=10mm,text margin right=5mm}
\setbeamertemplate{frametitle}[default][center]
\usepackage[many]{tcolorbox}
\usepackage{calc}
\begin{document}
\begin{frame}[fragile]
\begin{tcolorbox}[text width=\textwidth-1cm, text height=2.5cm]{}
\end{tcolorbox}
\begin{columns}[onlytextwidth]
\begin{column}{0.4\textwidth}
\begin{tcolorbox}[top=0pt, left=5pt,right=5pt, colback=blue!5!white, text height=4.3cm]
\end{tcolorbox}