PLS or Pls may refer to:
== Organizations ==
Partito Liberale Svizzero (Italian for Liberal Party of Switzerland)
Pioneer Library System, libraries operating in several counties in Oklahoma
Poculi Ludique Societas, Medieval & Renaissance Players of Toronto
Polska Liga Siatkówki (English: Polish Volleyball League)
Princeton Law School, a department of Princeton University from 1847 until 1852
Premier League Soccer, an Indian football league competition based in West Bengal
== Science and technology ==
Partial least squares regression, a statistical method (also known as "projection to la...