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5:01 PM
@Robusto when it's not about getting drunk
@M.A.R. You feel ulcers would be more of a risk than kidney/heart damage?
I read that proton thingies bring their own risks...
> - "I'm arresting you for downloading the entire Wikipedia."
- "Wait! I can explain everything!"
I wrote a really big article about DNAJC12 deficiency in the Russian Wikipedia, but I doubt it will be popular.
Well, it's big for a newly-started article.
5:32 PM
@Cerberus absolutely. Especially with ibuprofen
@Cerberus on chronic (> 6 mo.) use, they may increase the risk of some infections, bone fractures, and B12 deficiency. These effects are still actively debated, and given that PPIs are well-tolerated, adverse reactions very rarely lead to discontinuation. IOW, in healthy individuals their benefits far outweigh the risks.
@M.A.R. OK interesting, even at 200 mg of ibuprofen a day?
GI ulcer caused by NSAIDs and aspirin will still be a risk even with PPI use, but if you're taking ibuprofen for a long time, you need PPI.
@M.A.R. That is good to know! So the risks of proton thingies is less serious than the risk of ibuprofen at 200 mg.
@Cerberus yep. At any dose.
OK good to know.
I was taking the calcium carbonate pills instead of proton things.
Which only protect against some part of the ibuprofen risk.
I should really see my doctor.
5:40 PM
@Cerberus They can help with acute heartburn. You're pouring a base on acid and neutralizing it. Otherwise they have no other physiological roles (well calcium carbonate is also a calcium supplement)
When a pill is disintegrating, you momentarily have a very high concentration of its drug, which can cause damage. Antacids and H2 blockers (e.g. famotidine) help with that, as do PPIs.
Right, because the stomach acid increases the risk of ulcers?
But as I said, the very mechanism of how NSAIDs work causes a reduction in the protective mucus of the stomach against its own acid. So even if you used some NSAID skin patch, your gastric mucosae will still weaken.
Right I should really get off them. Just need to find something that actually works against aphthae.
Should just talk to the doctor.
@Cerberus yep. It's an acid and if you have a wound, it will cause more damage
That was what I thought.
5:48 PM
@Cerberus I've been thinking about that. It's possible you have some benign autoimmune disease, and those aren't aphthae. You mentioned before that corticosteroids didn't work, right?
@M.A.R. Oh, but that was only a nose spray, purely for nasal issues.
I've never really asked my doctor about aphthae.
Isn't ibuprofen supposed to prevent those?
Have you tried, say, triamcinolone oral paste?
Never heard of it!
I can ask my doctor.
I've heard they used to prescribe a mouthwash here, but I think it was forbidden because it was bad for your teeth.
I've tried the (non-prescription) stuff you need to apply to individual aphthae, which is a pain to use and doesn't have much effect.
@Cerberus it can help, they're often inflammatory in origin too. But there could be drugs with fewer adverse effects that achieve the same or better results
@M.A.R. Yeah, I was thinking the same thing.
5:52 PM
Corticosteroids are scary drugs, but topical application means less than 1 percent of the drug will enter your circulation
I take the ibuprofen because it is a miracle drug for me, I used to have bad aphthae and bad acne (the kind takes takes months to heal), and ibuprofen clears up both 100%, I'm all clear now.
But, yeah, if it's unhealthy...
And if it is some mild autoimmune disease, drugs such as colchicine may be considered
Let me Google those...
Sometimes antibiotics are prescribed against acne, like minocycline. Might that also help against aphthae?
@Cerberus my advice is to get a proper diagnosis, maybe even from a specialist
@Cerberus it's possible. The main reason tetracyclines are prescribed for acne is they possess anti-inflammatory properties
@M.A.R. Good advice.
5:57 PM
Topical tetracycline may discolor the teeth a little though, so probably not a good choice
@M.A.R. Right, that makes sense.
I used to take minocycline pills.
I believe they helped against acne. Didn't have aphthae then.
Maybe I could try that again, or doxycyline.
But, yeah, self-diagnosis and self-medication...
It must be great for you, though, being able to diagnose yourself quite a bit!
6:14 PM
@Cerberus because of the uniqueness of my situation and the drugs I take, it's actually really difficult for me to diagnose something in myself, regardless of the fact that pharmacists always lag behind physicians when it comes to clinical practice (except for clinical pharmacists maybe)
@M.A.R. That makes sense. Even so, you have more of an idea of what the options might be, or of what might be going on, that most people.
7:04 PM
@M.A.R. Interesting. I always thought they were killing the acne-causing bacteria.
Incidentally: IME acne is the one bad side effect of the all-milk diet. Other than that, it cures all illnesses.
Including schizophrenia and cancer and herpes?
@Cerberus Of course. For cancer you might need to warm the milk up first.
When was the last time you saw a baby cow get schizophrenia? Never, because they're on an all-cows-milk diet.
7:21 PM
Solid reasoning.
They don't get herpes either, except in Alabama. Maybe the milk is less good there?
8:13 PM
@alphabet except for lactose intolerance
@alphabet schizophrenia in humans usually starts in the 20s. If you had a good test for schizophrenia in young cows, then we can talk.
I had an uncle who decided to follow an all-meat diet when he was in his 20s.
After a few months, his doctor was extremely surprised to diagnose a case of scurvy.
Yesterday I was walking past State Hospital 40 and saw another man without the lower part of one leg, in a wheelchair. The fifth such man this year.
@jlliagre Wow
8:30 PM
@CowperKettle Unfortunate. Neither Ukraine nor Russia has signed the international convention forbidding anti-personnel landmines, which likely contributes to this. (The US hasn't signed it either.)
@jlliagre The all-milk diet has the same risk. Cows can make their own Vitamin C so they don't need to provide it in their milk.
@Mitch Easy. The schizophrenic cows think the humans are out to kill them and sell their body parts.
I don't think -any- cows are aware of that
Tucker Carlson thinks Ukraine blew up the dam. He also went on a rant about Zelensky's ugly tracksuit.
@alphabet I would think it's more paranoia than schizophrenia.
I remember an old comic strip about a dog who was a conspiracy theorist; he kept claiming that "the humans are putting microchips in us"
It's not inconceivable that some mammalian mental processes, like thinking counterfactually, could be over stimulated leading to what might be considered in the schizophrenic direction.
@alphabet also shock collars
8:36 PM
@alphabet Reminded me of this news report
Tucker Carlson has a new show on Twitter. It's about as hinged as you'd expect
He's run out of hinges
His first episode was about Ukraine. His second was about pedophilia. I'm sorry I watched.
I can guess what the third will be
I'm betting either "racism against white people" or "gender ideology"
8:43 PM
Only if the AI is "woke"
Anyway I've heard Russian state TV has already plugged him. I'm guessing his show will be a big hit there.
I'm surprised he doesn't have a show with Russia Today yet
Still brushing up on his blyat
He could co-host a morning show with Igor Girkin. Honestly, it'd be better than the one CNN made
@CowperKettle Best song out of Russia since the VDV one
A comment on that one:
> My Ukrainian neighbour loved this song so much he broke my window to listen
> Perfect music to conduct a contested airdrop on an airfield without proper air, ground or artillery support.
Peter Cooper of New York, presidential candidate of the Greenback Party.
He could use an afro hair pick in his beard.
9:04 PM
Santa for President
When Putin in 2018 removed real candidates from the election, there was this action in Yekaterinburg.
It's a set phrase indicating "We don't give a fuck" (похуй, пляшем)
Yekaterinburg had one of the strongest protest against the pseudo-election
It's unimaginable now. Such a protest would be harshly put down.
9:29 PM
@CowperKettle Business up top, party down below :p
@alphabet Don't you have anything better to do than watch Tucker Carlson?
Looks like he was very famous, this Cooper.
I never knew of him. He made the first US locomotive.
The Cooper Union speech or address, known at the time as the Cooper Institute speech, was delivered by Abraham Lincoln on February 27, 1860, at Cooper Union, in New York City. Lincoln was not yet the Republican nominee for the presidency, as the convention was scheduled for May. It is considered one of his most important speeches. Some historians have argued that the speech was responsible for his victory in the presidential election later that year.In the speech, Lincoln elaborated his views on slavery by affirming that he did not wish it to be expanded into the western territories and claiming...
@Laurel A mullet beard?
@Robusto Yes
9:35 PM
It makes me want to go google and look at the facial hair of centuries past, which is something I've never done before
> Cooper Union offered open-admission night classes available to men and women alike. The classes were non-sectarian, and women were treated equally with men.
> His son Edward and his son-in-law Abram Hewitt, both served as Mayor of New York City.
> The low levels of BH4 in young children with ASD has been proposed to be related to high NO production in response to excessive inflammation and overactivation of the immune system mdpi.com/2076-3921/12/5/1037
@CowperKettle ha, I saw just the picture and was like, hey this guy looks like beardless Lincoln XD
Amazing how tetrahydrobiopterin/folate metabolism are intertwined with mental diseases.
Just days ago I read an article about the overproduction of NO in autism.
At the same time, in chronic fatigue syndrome, BH4 may be elevated. Causing orthostatic intolerance.
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