Change of Heart

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3:34 AM

This is something that I have been considering for quite a while based on a fictional story I had read. An unconscious individual must undergo emergency surgery in order to stabilise them and prevent the patent's death. This medical intervention is happening without the patent's explicit consent...

medical-ethics

4 hours later…

Feeds

7:20 AM

Q: What is the purpose of the "observation cohort" in a clinical trial?

Quote from a clinical trial report (JGOG3022 trial): Patients who were scheduled to receive bevacizumab concomitantly with platinum-based combination chemotherapy after PDS or IDS were included in the observation cohort of this study before enrollment. This observation cohort is not mentio...

cancer terminology clinical-study

2 hours later…

Feeds

9:27 AM

Q: Difference between Eisenmenger syndrome and ventricular septum defect

What is the difference between Eisenmenger syndrome and ventricular septum defect? They are both related to hole between the two ventricular, right?

heart-disease

3 hours later…

Feeds

12:22 PM

Q: the treatment of hypopharyngeal squamous cell carcinoma

What is the best treatment for the treatment of hypopharyngeal squamous cell carcinoma? Is there a recommended hospital and doctor?

treatment

5 hours later…

Feeds

5:10 PM

Q: Are "data cut off" and "data lock" the same thing in a clinical trial?

Quotes from a clinical trial report (JGOG3022 trial): Follow-up was terminated in February 2017 and data were locked in October 2017. Of the 346 patients enrolled, ineligible patients and patients who did not receive bevacizumab were excluded, and the remaining 333 patients were classified as...

terminology clinical-study

2 hours later…

LangLangC

7:08 PM

@Narusan Ah just half-way through his pamphlet… Very nice essay, but alas, quite guru-like. We wouldn't allow that here: No references! ;) But a worthwhile read. From a philosophical viewpoint. I wonder whether you remember that statistical statement correctly. Do you have a presentation for that?

2 hours later…

Feeds

9:12 PM

Q: How exactly is wheat flour healthier than white flour?

I've read the question about Why is White flour unhealthy. It seems like raw/bleached/white flour is just the endosperm component, but that wheat flour contains the endosperm along with the fibrous portions (germ and bran). White flour gets knocked a lot for it being really close to sugar and b...

nutrition healthy-cooking fibre cooking

1 hour later…

Narusan

10:34 PM

@LangLangC No, I don’t. But essentially: He started his argument somewhat reasonably: If you have a cohort of 10^9, and 10 people in the control group get sick while 1 person in the intervention group gets sick, the intervention prevents 90% with an incredible significance. However, as the absolute risk is super low, it doesn’t mean everybody should receive the intervention.

He then went on to state that in fact, for any study, the larger the cohort the less reliable the study is, which is some bullshit. He also got a few medical facts wrong I googled on the spot (can’t remember what they were, however).

His „trick“ is that he states some really sensible truth, but then has escapades of absolut rubbish.

LangLangC

@Narusan That's what I suspect: medical statistics are incredibly difficult to interpret 'right' – and pure sample size is sometimes quite counterintuitively misleading (de.wikipedia.org/wiki/Repräsentativität) effect size, significance, in a study, vs real-world outcomes are sometimes quite confusing.

When reading papers I can scan quite quickly thru the text, but in the statistics department I have to read it 3x at least and slow down to a halt.

That's why I ask. If he said "sample size is no guarantee for quality" it's not wrong. If said exactly what you quoted, he would have to quote a bit more support to convince anyone…

That's "sheer sample size". The usual psycho-BA experiment with "6 participants felt much better/ showed absurd behavior; therefore since the stone age we all are for evolutionary reasons …" is of course the other extreme.

Narusan

11:07 PM

@LangLangC He said exactly that, and he was asked to repeat it.

LangLangC

@Narusan Without backup? No wonder the audience probably erupted?

Feeds

Q: How much variability is there in the potency of stimulates between different individuals?

I was wondering how much variability is there in the response that different individuals have to a fixed stimulant at a fixed dose? I am assuming that most stimulants would have the same "variability" curve, but if asking about all stimulants would be too broad, feel free to focus on a specific ...