In experimental there is now
luatex 1.11.0 with harfbuzz 2.5.1
It follows from the development of harftex by K. Hosny.
Please note that the code is
1) in experimental
2) marked as work in progress
so it can stay as is, it can be changed , it can be removed completely.
We have relaxed the constrain "only C" so a recent C++ is required;
but we keep the contrain on the size the must be "small" ---
the current size of the binary is around 8M so still good.
Feedbacks are welcome: it would be nice to have it in texlive 2020