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Consider $R=k[x,y]_{(x,y)}/(xy)$ and $S=R[\frac{x}{x+y},\frac{x}{x^2+y},\dots]$, then $(R:_{Q(R)}S)$ contains $y$, so it is non-zero. Suppose that $d \in (R:_{Q(R)}S)$. Then for all $n$, we have $d\frac{x}{x^n+y} \in R$, so $$dx \in \bigcap_{n \geq 1} (x^n+y) \subset \bigcap_{n \geq 1}(x^n,y)=(y)...