public function SetData($Query, $Conf = [])
    {
        try {
            $conn = $this->DataBaseConnection($this->CheckServerSwitch($Conf)); //establece la conexion
            $conn->setAttribute(PDO::ATTR_ERRMODE, PDO::ERRMODE_EXCEPTION);
            $conn->beginTransaction();
            $conn->exec("set names utf8");
			foreach ($Query as $DB_2USE => $QArr) {
				$conn->exec('USE ' . $DB_2USE);
				$stmt = $conn->prepare($QArr['query']);
				if ($this->CheckIfStartWith(['str' => $QString, 'beg' => 'UPDATE'])) { //valida si es un Update

$result = '';
        if (is_array($clouse['value'])) {
            $result = [];
            foreach ($clouse['value'] as $key => $value) {
                $result[] = $this->GetCleanPOST(['key' => $key, 'value' => $value]);
            }
        } else {
            if (strpos($clouse['key'], 't_area_') === false) {
                if (strpos($clouse['key'], 'checkbox') !== false) {
                    $result = (true == $clouse['value']) ? true : false;
                } else {
                    $result = trim(addslashes(strip_tags($clouse['value'])));

<?php
public function SetData($Query, $Conf = [])
    {
        try {
            $conn = $this->DataBaseConnection($this->CheckServerSwitch($Conf)); //establece la conexion
            $conn->setAttribute(PDO::ATTR_ERRMODE, PDO::ERRMODE_EXCEPTION);
            $conn->beginTransaction();
            $conn->exec("set names utf8");
            foreach ($Query as $DB_2USE => $QArr) {
                $conn->exec('USE ' . $DB_2USE);
                $stmt = $conn->prepare($QArr['query']);
                if ($this->CheckIfStartWith(['str' => $QString, 'beg' => 'UPDATE'])) { //valida si es un Update

$dbquery =[
        'DB1'=>[
            '0' =>[
                'query' => 'INSERT INTO table_name_1(column1,column2) VALUES (?,?)',
                'column1'=>value11,
                'column2'=>value12,
            ],
            '1' =>[
                'query' => 'INSERT INTO table_name_2(column1,column2,column3,column4) VALUES (?,?,?,?)',
                'column1'=>value21,
                'column2'=>value22,
                'column3'=>value23,
                'column4'=>value24,
            ],

hago esto:
$stmt->bindValue($count, $value);
que estoy asumiendo es lo mismo que hacer lo que dice aqui de hace 12 años:
php.net/manual/es/pdo.begintransaction.php#90239

for($i=0; $i < 10; $i++) {
            $stmt->bindValue(1, $i, PDO::PARAM_INT);
            $stmt->bindValue(2, 'TEST', PDO::PARAM_STR);
            $stmt->execute();
            sleep(1);
        }
        $conn->commit();