@tlfong01 Thank you for the extended effort. The BBB just drives the pins on the Hbridge and that is about it. I made a GUI to drive the motor through the BBB. Does that answer your question?

(1) Ah, yes, you answered my question. I originally wrongly thought that you only used manual push buttons to input 5V, 0V to the motor driver. Now if you have been using BBB code to control the couple of pins of the motor driver, and that if your BBB code runs well, except the drivers intermittently get fried, at least it is likely that your code is OK.

(2) I also have a closer look at your two motor drivers, and found them more or less OK, and as you said, there are only a 3 or 4 signal lines (Note 1), so it is not easy to go wrong.

(3) So my suggestion is, if you want a reliable setup, to try the BTN7971B, which has software current sense and software alarm alert signal, and also over temperature protection, which seems not available in other driver your are using, or plan to use (Pololu one).

(4) Note 1. There is one catch though. If you skim my locked answers on BTN7971B, you would see me mentioning two wiring/control methods: (a) Hanson Tech's method of not following the BTN7971B datasheet, and (b) the traditional L298N wiring/signal routing, coding method. As you read in my description, using the HT method, there is a possibility of frying the driver, if signals are not correctly applied. There is 5% chance that your drivers are fried this way.

Anyway, if you are going to try BTN7971B, and if the frying problem disappears, then it means BTN7971B is at least a workaround. BTW, your two drivers seem dsicontinued and no longer available in the market, and Pololu is US$30 compared to Infineon US$20, so it is no harm trying the Infinion way. We have diverted a bit too far, so if you have any questions on BTN7971B, perhaps you can ask a new question, specifically on BTN7971B. Good luck. Cheers.

This is the wiring that causes frying:

And the post: electronics.stackexchange.com/questions/559986/…