This could dovetail nicely with an existing campaign off mine where the PCs recently put right a serious disruption in the world: an earthquake dislodged an super-powerful artifact from its resting place--in the hands of a suspended-animation titan. Not being held, its magic leeched out in strange ways.
(The titans rest in their slumber as ages pass; they only awaken when dragons come to threaten the land. The PCs don't know any of that, though, just "what the hell are these 200-ft. people doing!?")